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In this context, GLP-1RAs are able to target six of these biological abnormalities, whereas other agents such as metformin target mainly one (Fig

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adults with overweight or obesity who initiated GLP-1 therapy between 2019 and 2024

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(Cell Metab, 2022), the discovery paper that established the relative potencies and signaling biases versus dual-agonist comparators

Challenges in the optimization of multi-receptor agonists Although multi-receptor agonists such as tirzepatide exhibit enhanced effectiveness, their development poses distinct obstacles that need careful attention