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Prunes or prune juice, which contain both fiber and sorbitol (a natural laxative), may be particularly effective

The cost-effectiveness calculation also depends on treatment duration

doi:10.1007/s00395-015-0518-1 60

The GLP-1RA market is on track for substantial expansion, as many companies prepare to introduce new injectable and oral options

liraglutide significantly decreased body fat and waist-to-hip ratio (p=0.003), and exenatide reduced waist-to-hip ratio but had minimal weight loss benefits.[6] In the STEP1 study, adults with obesity without diabetes receiving semaglutide 2.4mg plus lifestyle interventions had a mean weight loss of 14.9% from baseline in addition to improved fasting glucose and lipids, increased physical activity, and decreased fat mass.[7] The SURMOUNT-1 trial demonstrated that tirzepatide 5mg, 10mg, and 15mg caused significant improvement in weight, total body fat mass, lipids, systolic and diastolic blood pressure, and fasting insulin levels.[5] Cardiovascular disease risk reduction Diabetes represents a major risk factor for cardiovascular disease

Acute kidney injury: 0.7%