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Both classes are resistant to the enzymatic degradation seen for native GLP-1, which is cleaved by the DPP-IV enzyme to generate inactive metabolites and intact GLP-1 forms with low affinity for the GLP-1R

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doi: 10.1016/s0091-3057(97)90017-4

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By enhancing the secretion of insulin, delaying gastric emptying, and suppressing appetite, semaglutide effectively aids in blood sugar control and promotes weight loss

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