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Its also associated with a feeling of losing control during the binge, as well as feelings of shame or guilt afterward ( Bulimia nervosa involves the same binge-eating behavior as with BED but also includes behaviors people use to compensate for the effects of binge eating, such as self-induced vomiting ( In a small 12-week study in people with BED who had excess weight, people who took a phentermine and topiramate drug combination experienced significant reductions in binge-eating episode frequency ( In another 12-week study, people with BED or bulimia nervosa received the drug combination or a placebo ( Over 28 days, treatment with the phentermine and topiramate combination decreased the participants number of binge-eating days from 16.2 to 4.2