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As shown by Sun et al., treatment with GLP-1RAs reshaped gut microbial composition by increasing the abundance of beneficial genera such as Lactobacillus and Bifidobacterium

15 Conclusions In conclusion, the available data on endocrine disorders associated with PWS suggest that there is no clear genotype-phenotype association

The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies

145:e722-e759

Insulin increases glucose disposal by glycogen synthesis and lipogenesis in the liver, and promotes the uptake of glucose and conversion to glycogen or triglycerides by skeletal muscle and adipose tissue

this has not been demonstrated in humans, and the relevance to people is uncertain
