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But the drop goes beyond what physics predicts

Increased adiponectin levels are associated with a lower risk of cardiovascular disease

HbA1c variability predicts cardiovascular complications in type 2 diabetes regardless of being at glycemic target

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It has been shown that adiposity induces the activation of NLRP3 inflammasome, which activates the synthesis and release of pro-inflammatory cytokines such as IL-1 and IL-18 through induction of peripheral IR or by activating neuroinflammatory cascades trigger AD neuropathology (Litwiniuk et al