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It reduces systolic blood pressure by 14 mmHg, lowers non-HDL cholesterol by 15-20%, decreases triglycerides by 35-45%, and reduces inflammatory markers like hs-CRP

Both retatrutide and tirzepatide are made by Eli Lilly and belong to the incretin-based class of weight loss medications

Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction

Int J Cardiol 2010

In T2DM ATEC, basal phosphorylation of IGF-1R was increased 2-fold (p=0.0127, n=14/12)

Investigators included individuals with type 2 diabetes, hemoglobin A1c, aged 50 years or older at time of consent, and had at least 1 of the following conditions: coronary heart disease, cerebrovascular disease, symptomatic peripheral artery disease, or chronic kidney disease