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For patients with a multi-year treatment horizon who want to avoid future disruption, Roman's hybrid model is a form of insurance

[DOI] [PubMed] [Google Scholar] 8.Incretin-based drugs and intestinal obstruction: a pharmacovigilance study

It causes a delay in gastric emptying

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This was further reinforced in their latest release in 2024 [61,62]

Taste Changes : Altered taste can reduce appetite and enjoyment of food