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The Medicare GLP-1 Bridge is intended to expand access to certain FDA-approved GLP-1 weight-loss drugs through a temporary demonstration program currently scheduled to run through December 31, 2027

This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

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This review synthesizes current evidence on glucagon-like peptide-1 receptor agonists (GLP-1 RAs), a well-studied AOMs, focusing on their effects on sarcopenia through mechanistic insights and clinical considerations in older adults

Several patterns appear consistently: Loss of lean muscle mass Inadequate protein intake Nutrient deficiencies, particularly vitamin D and magnesium This matters because muscle mass plays a direct role in supporting skeletal health