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This article examines clinical safety data, GI mechanisms, and how genetic predispositions may influence medication tolerance in IBD patients see

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The data supports continued use in: Type 2 diabetes Obesity and metabolic syndrome Patients with cardiometabolic risk factors Reasonable caution is still appropriate in individuals with: Active pancreatitis Recurrent idiopathic pancreatitis Severe hypertriglyceridemia until corrected

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