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Baraona, E

This synergistic combination is why it outperformed earlier GLP-1 monotherapies like semaglutide

SURMOUNT-1: A Phase 2 trial that included 478 overweight patients without a diabetic condition

Tirzepatide side effects Common Side Effects The most common tirzepatide side effects are: Diarrhea Vomiting Constipation Nausea (mild to moderate) Decreased appetite Abdominal pain

Its dual mechanism of action targets the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, which are crucial for regulating insulin secretion, improving insulin sensitivity, and reducing glucagon levels

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