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Due to their preclinical testing and lack of comparison with other dual receptor agonists such as tirzepatide, further studies are needed to determine whether the effects of these unimolecular compounds are superior to those of clinically tested drugs

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Exendin-4 may affect -cell number by stimulating cellular proliferation 21, 22

Another meta-analysis conducted on adolescents with overweight/obesity without T2D reported that GLP-1RAs had a better anti-obesity effect when compared to placebo or lifestyle modification (semaglutide is better than liraglutide and exenatide for weight control) [35]