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Unlike many hormones or signaling molecules produced elsewhere, MOTS-c is encoded within the mitochondrial genome, specifically the 12S rRNA

But many patients are noticing an unexpected side effect: a hollow, gaunt appearance in their faces that can make them look older than before their weight-loss journey began

Like any effective medication, side effects are possible, often mild gastrointestinal symptoms

Can J Diabetes 2020;44:592-6

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Teaching Patients About Side Effects and What to Expect Educating patients about what to expect during GLP-1 treatment is crucial