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At Josie, we hear it all the time from women in their late 30s, 40s, and 50s: Im doing everything right eating less, moving more so why isnt it working anymore? In this article, well break down how GLP-1s work with your biology, what to expect, and why this approach is helping so many women feel like themselves again

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Clinical trials show that tirzepatide, a dual GLP-1 and GIP receptor agonist, produces weight loss signals earlier in many patients compared to single-mechanism GLP-1 drugs, though individual response depends on metabolism and genetic sensitivity to these pathways