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Given the different indications, a randomized head-to-head comparison between liraglutide 3.0 mg, daily subcutaneous injection, and semaglutide 1.0 mg, weekly subcutaneous injection has not been done

GLP-1RAs reduce tumor necrosis factor-alpha (TNF-_), nuclear factor kappa B (NF-gB), interleukin (IL)-17, and IL-23 signaling

These effects are mild to moderate in most patients and do not prevent weight loss

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[1] When used as monotherapy in patients without diabetes, Zepbound carries a low intrinsic risk of causing hypoglycemia due to its glucose-dependent action, as demonstrated in clinical trials

At the same time, a well-rounded diet supports the medications role while building habits that can stick for the long haul