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Narrow Impact: Any benefits are limited to Medicare beneficiaries only

doi: 10.1007/BF00291078

Seek medical advice if leg cramps: Occur frequently or are severe , significantly affecting quality of life or sleep Are accompanied by muscle weakness, numbness, or persistent tingling , which may suggest worsening diabetic neuropathy or other neurological conditions Are associated with swelling, redness, warmth, or tenderness in the leg, which could indicate deep vein thrombosis (DVT) or infection

Furthermore, the improvements in glucose homeostasis following prebiotic treatment are dependent on GLP-1R signaling, implicating that prebiotic-induced alterations in the microbiome restore the gutbrain axis 257

If the number of tests was large, we computed the False Discovery Rate (FDR) to adjust for the multiple tests

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