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Diet-induced weight loss (WL) leads to increased hunger and reduced fullness feelings, increased ghrelin and reduced satiety peptides concentration (glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK) and peptide YY (PYY))

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It is a serious, chronic, progressive disease tied to type 2 diabetes, cardiovascular disease, hypertension, stroke, fatty liver disease, sleep apnea, kidney disease, certain cancers, joint disease, depression, reduced mobility, and a lower quality of life