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Discontinuation rates owing to adverse events were 4.1%, 6.9%, 11.3%, with retatrutide 4mg, 9mg, and 12mg, respectively, compared with 4.9% with placebo, the study results revealed

There was also a trend that those with a higher baseline SBP, both on semaglutide and placebo, had their anti-hypertensive treatment escalated more often

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Patients with certain genetic profiles may experience stronger satiety signals and tolerate empty-stomach injections more comfortably, while others benefit from eating first

Summary: GLP-1 receptor agonists are prescription medications that may support weight management during perimenopause by suppressing appetite and delaying gastric emptying, but they are not specifically indicated for hormonal changes and require strict NHS eligibility criteria

It brings together the clinical support of GLP-1 medication, a gentler dosing approach, more manageable pricing, and the behavior-change tools Noom is known for