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Organization's director-general says medication could help reduce harm of obesity for millions of people.

Glucagon-like peptide-1 receptor (GLP-1R) is a versatile therapeutic target that regulates glucose homeostasis, cardiovascular function, neuroprotection, and immune responses

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As a result, dozens of upstream and downstream neural targets of 5-HT have been identified, revealing a multitude of neural circuits involved in mediating the anorexigenic effect of 5-HT

The concept of type 2 diabetes remission is evolving rapidly, and gaining wide public and professional interest, following demonstration that with substantial intentional weight loss almost nine in ten people with type 2 diabetes can reduce their HbA1c level below the diagnostic criterion (48 mmol/mol [6.5%]) without glucose-lowering medications, and improve all features of the metabolic syndrome