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Abdominal obesity In a 12-month clinical trial published in 2010, which involved 404 HIV-infected patients with excess abdominal fat, the group that received 2mg of tesamorelin per day saw an 18% decrease in visceral fat compared to placebo.9 There are two things to note in order to appreciate the full scope of these findings: Visceral fat (i.e., fat accumulation around the abdominal organs) is famously stubborn and cant be burned selectively through exercise

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In addition, bile acids activate the GPCR of PP cells, and Takeda G-protein receptor 5 (TGR5) stimulates PYY release, whereas H 2 S produced by sulfate-reducing commensal bacteria in the colon inhibits TGR5-dependent PYY release involving the PLC-/calcium ion pathway ( Therefore, while it appears that PYY possesses formidable weight-reducing properties, exogenous PYY negatively regulates bone mass and strength in adults and has long-term deleterious side effects on bone, including increasing the risk of fracture, so care should be taken in treating obesity with PYY

Andrew Gostine Andrew Gostine, MD, MBA, is an accomplished healthcare professional, passionate about leveraging artificial intelligence in the clinical setting

We all have very similar big picture goals