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CMS did not explain the rationale behind their approach.) CMS specified that if the 80% threshold was not met, CMS would not move forward with the BALANCE Model in Medicare in 2027, and that appears to be what occurred, as CMSs April 21, 2026 announcement suggests

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Liraglutide had a limited effect on the POMC-MC4R pathway deficiency, whereas semaglutide was expected to have a more potent effect

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