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GLP-1RAs not only have the potential to treat the above-mentioned diseases but also ameliorate the co-morbidities simultaneously, which is important for patients with autoimmune/autoinflammatory diseases combined with metabolic diseases

Glucagon is released from the endocrine pancreas in response to a meal and binds to G protein-coupled receptors on skeletal muscle and the liver to exert its glucoregulatory effects

[DOI] [PubMed] [Google Scholar] 187.Purwana, I

Journal reference: Budini, B., Luo, S., Tam, M., et al

The realm of GLP-1 receptor agonists is changing

In this article we provide an overview of the pathophysiology and management of NASH, with a special focus on the pharmacological effects and possible mechanisms of GLP-1 mimetics in treating NAFLD/NASH, including dual and triple agonists at GLP-1R, glucose-dependent insulinotropic polypeptide receptor or glucagon receptor