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Several agents have demonstrated histological and biochemical effects by targeting core pathophysiological pathways

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This trial was stopped early because the benefits were so clear that continuing to give placebo was deemed unethical

Clinicians should also consider alternative medical explanations for new-onset fatigue, including thyroid dysfunction, anemia, sleep apnea (which may improve or persist despite weight loss), chronic kidney disease, or cardiovascular conditions

This approach aims to attenuate these responses and leverage a potential metabolic advantage (higher energy expenditure), particularly in insulin-resistant states, while helping to recalibrate the homeostasis of the brains hungersatiety circuits
