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Systematic reviews and meta-analyses of randomized trials have further confirmed that while GLP-1RAs lower body weight and fat mass significantly, they do not appear to exert an independent detrimental effect on skeletal muscle index beyond expected proportional reductions [25]

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Semaglutide (Wegovy): Designed for weight loss, clinical trials show an average reduction of 1520% of body weight over 612 months with proper diet and exercise