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however, endogenous GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) to GLP-1(936) which has a weak binding affinity to GLP-1R and was previously presumed to have no biological effects ( Figure 6 , treatment with exendin-4 (GLP-1R agonist) remarkably attenuated MG-induced the elevation of both intracellular and mitochondrial ROS levels, which had effects similar to those of GLP-1(936) ( Figures 6A, B , respectively)

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8 This plot demonstrates excellent agreement between the model and the clinical trial data (the data is from Figure 1B in Reference [8])

This drug works by targeting areas in the brain that control appetite

doi: 10.1007/s40265-022-01746-8

Disposal of unused or expired medication requires environmentally responsible approaches that also prevent accidental exposure or intentional misuse