soul trial oral semaglutide cardiovascular outcomes trial results SELECT The SOUL Study - by

61 In turn, Milani et al reported that male participants treated with liraglutide achieved greater weight loss and BMI reduction

This gradual progression differs sharply from starting at full doses, which often triggers significant gastrointestinal discomfort

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Stopping semaglutide after one month often results in appetite rebound within 13 weeks as GLP-1 signaling normalizes

Thus, more targeted, well-designed clinical trials are required for providing clearer evidence on the efficacy, optimal dose, and safety profiles of these drugs in AD and PD