how were glp 1 drugs discovered Evolution of GLP‐1 Receptor Agonists for Diabetes Treatment GLP-1 | Summary

1).29,32 With respect to the vascular system, rGLP-1 activation induces modest decreases in blood pressure,33,34 it has a vasodilator effect, improves arterial stiffness, and prevents atherosclerotic plaque formation-and has plaque stabilizing effects-through its anti-inflammatory and antiapoptotic effects as demonstrated in animal models.29,32,3538 Despite controversies about rGLP-1 expression in vascular smooth muscle and endothelial cells, studies have shown that arGLP-1 has antiproliferative effects on these cells,39 reduces oxidative stress, improves endothelial function, and increases nitric oxide production in experimental models.3540 In the heart they produce a discrete increase in heart rate (24 beats/min), although this does not seem to be associated with an increase in arrhythmias or cardiovascular events

Its structure is based on GIP but it also has amino acids in common with GLP-1

The remaining 158,349 patients who did not use GLP-1 RAs were enrolled as the GLP-1 RAs non-users group

Study design & population Using an active-comparator new-user cohort design [31, 32], we emulated three hypothetical active-controlled randomized trials comparing SGLT2 inhibitors, injectable GLP1 receptor agonists, and DPP4 inhibitors pairwise

The most practical ways GLP-1 therapy may support a medically supervised fatty liver plan include: Reducing appetite and food noise, which can support a calorie deficit Supporting weight loss, especially loss of excess visceral fat Improving blood sugar regulation in appropriate patients Reducing insulin resistance in some patients Improving triglycerides and other cardiometabolic markers in some patients Reducing the metabolic stress that contributes to liver fat Helping patients sustain lifestyle changes when appetite has been a major barrier This is why GLP-1 therapy should be viewed as one possible tool inside a broader metabolic plan

Zhang, J