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The prolong use of certain gut peptides such as PYY3-36 and GLP-1, seems to be rational, particularly, that the deficiency of these peptides in obesity has been documented (95)

Semaglutide improves cognitive function in HIV, effect mediated by decrease in inflammation

However, like many medications, it can have side effects

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PlexusDx offers the Precision Peptide Genetic Test, a $99 add-on after your first month of treatment that analyzes key genetic variants including GIPR rs1800437, GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313