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The influence of GLP-1 on the glucose-induced insulin secretion: effects on beta cell sensitivity in type 2 diabetic patients and controls

Circulating GLP-1 exists only at low picomolar concentrations, is rapidly inactivated by DPP-4 enzymes and is swiftly cleared by the kidneys (Mulvihill and Drucker, 2014)

D.KoyfmanA.LongB

The problem has only become more complex with the skyrocketing use of glucagon-like peptide 1 class (GLP-1) drugs, such as Ozempic and Wegovy

Research indicates that GLP-1 receptors are present in multiple organs, including the pancreas, heart, and kidneys, suggesting that GLP-1RAs have a broad range of pharmacological effects
