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The genetic test informs whether you're a stronger responder to single GLP-1 agonists or might benefit from combination therapy with tirzepatide, which activates both GLP-1 and GIP receptors

Nauck MA, and Friedrich N

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In addition, GLP-1RAs could adjust the levels of the satiety signal in the arcuate nucleus in the hypothalamus, thereby increasing satiety and reducing caloric intake (179)

Clinical trials have shown their efficacy and safety over several years, yet the possibility of long-term adverse effects remains a research focus

Study Data and Methods Cohort Identification We used the FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) 15 and product labels from Drugs@FDA 16 to identify all GLP-1 receptor agonists approved from 2005-2021 (see eMethods)