glp-1 agonist dementia Potential Role of Glucagon-like Peptide-1 Receptor Agonists in the Treatment of Cognitive Decline and in Diabetes Mellitus GLP-1 receptor agonist diabetes medications

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GLP-1 receptor agonists influence metabolism through three primary pathways: appetite modulation, glucose-dependent insulin secretion, and slowed gastric emptying

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For the short-acting GLP-1RAs (exenatide, liraglutide, lixisenatide), a study in Gut22 showed patients starting these agents had an 11% increased risk of being newly diagnosed with GORD when compared with the control group of patients with diabetes receiving alternative medications

The benefits of SGLT2i therapy also extends to CKD where there is a significantly reduced risk of decline in eGFR and progression to end stage renal failure, regardless of presence or absence of type 2 diabetes [23]