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Xiao et al

The reasons for problems with the translation of experimental results include limited penetration through the BBB, specific differences in pharmacokinetics, and variability in response to treatment due to genetic and metabolic factors
Taken together, these data suggest that obesity does not universally impair biologic efficacy but remains consistently associated with a higher inflammatory burden and increased comorbidity load

Enhancing NAD + biosynthesis promotes SIRT1- and SIRT3-catalyzed reactions, improving metabolic disorders such as weight gain, insulin resistance, and dyslipidemia associated with an HFD [171]

Norwood, R
