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By Donna Monthei, RDN, LD | Originally Published: March 6, 2025 | Medically Reviewed on June 18, 2026 As a growing number of people turn to GLP-1 medications like Ozempic for weight management, a new term has entered our vocabulary: Ozempic face. This phenomenon refers to the facial aging and volume loss that can occur with rapid weight loss from these medications

This can make it harder to maintain a balanced diet and increases the risk of reverting to old eating habits

The comparison can help readers understand why some people use a single-agent DPP-4 inhibitor while others use a fixed-dose combination

The Centers for Disease Control and Preventions 2021 National Health and Nutrition Examination Survey estimates that clinical obesity prevalence was 41.9% in the period of 2017 through March 2020, and troublingly, this number constitutes a significant jump from 1999, when prevalence was estimated at 30.5%