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Until recently, those medications meant having to give yourself an injection

11.4 Lean Mass Preservation Is Foundational Preserving lean mass: Protects metabolic rate Supports long-term weight maintenance Preserves functional capacity Maintains micronutrient intake indirectly Protein adequacy often has greater downstream impact than broad micronutrient supplementation

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The researchers compared the one-year risk of HF hospitalization or death in new users of each GLP-1 drug to the risk of those outcomes in a placebo group of patients taking sitagliptin, a diabetes drug known to have no impact on HFpEF

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At week 12 people assigned to placebo or 1.2, 1.8, or 2.4 mg of pemvidutide had absolute LFC reductions of 0.2%, 8.9%, 14.7%, and 11.3%