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Study shows that GLP-1 receptor agonists in type 2 diabetes patients offer protection against dementia.

In a newly published study with Elisabetta Patorno and colleagues, we examined severe motility-related GI events, including gastroparesis, gastrointestinal obstruction, and severe constipation requiring hospitalization, among adults with type 2 diabetes initiating GLP-1 RAs vs SGLT-2 inhibitors

Given that Gq is a key player in the amplification of GSIS, particularly under diabetic conditions, these findings highlight a GLP-1 receptor-centric pharmacological profile that underlies the potent effects of this multi-receptor agonist