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Contributors from my own department are mentioned in the Acknowledgment

Abbreviations ADA: American Diabetes Association CV: Cardiovascular CVOTs: Cardiovascular outcome trials GLP-1RA: Glucagon-like peptide-1 receptor agonists HR: Hazard ratios MACE: Major cardiovascular events SGLT-2i: Sodiumglucose transporter-2 inhibitors T2DM: Type 2 diabetes mellitus References Giugliano D, Maiorino MI, Longo M, Bellastella G, Chiodini P, Esposito K

Most patients reach their maintenance dose within four to twelve weeks of starting semaglutide

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Some studies and clinical experience suggest that older people on GLP-1s need careful attention to muscle mass and protein intake to avoid functional decline

N Engl J Med (2021) 384(11):989