combining glp-1 receptor agonist with dpp-4 inhibitor not recommended guideline Dipeptidyl peptidase-4 (DPP-4) inhibitors: dosing, dose adjustment and The Role of DPP-4 Inhibitors

4 Receptor binding activates adenylate cyclase causing intracellular accumulation of cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) and triggers insulin secretion

12 Although larger-scale studies are yet to explore the effects of GLP-1 RAs on cardiac structure and function, available evidence suggests that GLP-1 RAs may improve systolic and diastolic function in individuals with T2D who are at high risk of CVD and reduce infarct size after acute MI

A structural basis for amylin receptor phenotype

Brazg R., Xu L., Dalla Man C., Cobelli C., Thomas K., and Stein P

found that hypoglycemia was less common with liraglutide 3.0 mg than with placebo in individuals with overweight or obesity and insulin-treated type 2 diabetes [43]

Hanyaloglu A