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Their combined benefits in both glycemic control and obesity management have positioned GLP1 drugs as preferred options among clinicians seeking comprehensive solutions for complex metabolic conditions

Tirzepatide (Mounjaro, Zepbound) targets two pathways and tends to produce greater weight loss in head-to-head studiesroughly 20% body weight loss on tirzepatide vs 15% on semaglutide

GIP/GLP-1/GCGR, triple glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and glucagon receptor agonist

A PPAR-dependent mechanism was also found to regulate the expression of the Gipr in beta cells by glucose and fat [22]

Data from the forthcoming FLOW trial are also awaited