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Although long-term safety and efficacy require further evaluation, current evidence positions GLP-1 RAs as promising therapeutic agents in translational geroscience, with the potential to mitigate age-related physiological decline and promote a longer, healthier lifespan.

Among these, 14511 patients initiated semaglutide and 69700 initiated sitagliptin between 1 January 2018 and 31 December 2020

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GLP-1GLP-1 91%88%

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Clinical Trial Registrations NCT04559815 (Canada), NCT04537637 (Denmark), NCT05230615 (Italy), NCT04601740 (the Netherlands), NCT04601753 (Sweden), NCT04537624 (Switzerland), NCT04862923 (UK).