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Medically supervised tapering typically reduces the dose by 10-25% every 1-2 weeks to minimize withdrawal symptoms like muscle aches, nausea, and anxiety that peak around day 3-4

Moreover, abnormalities associated with hypertension, such as insulin resistance and hyperlipidemia (high lipid levels), can be worsened by some anti-hypertensive medications

Kildegaard J, Buckley ST, Nielsen RH et al (2019) Elucidating the mechanism of absorption of fast-acting insulin aspart: the role of niacinamide

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Gastrointestinal side effects also warrant attention: both medication classes can affect appetite and digestive function, though in opposite directions