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Despite the constant innovative cycle of measurement of GLP-1 receptor agonists, and specifically SMG, there are still some issues and uncertainties that should be explored in future studies: (1) Considering that obesity is a chronic, progressive and relapsing disease [182], it is still necessary to determine the optimal duration of SMG therapy for weight control and to identify potential needs for medication adjustments based on individual characteristics

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Long-acting agents seem to have a lower incidence of gastrointestinal adverse effects (166), likely due to tachyphylaxis in gastric emptying with sustained GLP-1R stimulation