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In sum, our data document the beneficial effects of GLP1-based multi-agonists, and particularly GLP1/E, in two models of PCOS, with the identification of optimal doses, main metabolic and reproductive effects, and tenable hypothalamic pathways targeted

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Semaglutide (GLP-1 receptor agonist) improves systemic metabolism, leading to a higher rate of MASH resolution as well as significant fibrosis improvement