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It also bumps up against the mechanism of action of GLP-1s, which are approved by the FDA for long-term weight management because their discontinuation can lead to weight regain

The STEP programme, a series of tests examining the effects of semaglutide, shows an outstanding average weight reduction of 14% to 15% of participants body weight
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2019 doi: 10.1016/j.diabet.2019.101117

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Serious Reactions: Hypersensitivity reaction, anaphylaxis, angioedema, acute kidney injury, chronic renal failure exacerbation, pancreatitis, cholelithiasis, cholecystitis, syncope
