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Weight loss plateaus are common after several months on GLP-1 therapy

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Pharmacologic therapies, including glucagon-like peptide-1 receptor agonists and thyroid hormone receptor- agonists, improve histologic endpoints and fibrosis regression, although heterogeneity among clinical trials precludes direct comparison

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While peptide drugs have a wide range of therapeutic applications, their relatively short half-life has been a challenge, attributed to poor metabolic stability and a fluid dynamic radius below the glomerular filtration limit of the kidneys.

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