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Potential adverse effects, such as gastrointestinal issues and long-term safety concerns, also limit widespread adoption

The hypothalamus, particularly the arcuate nucleus, contains GLP-1 receptors that modulate hunger and satiety signals

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Discovery and development of exenatide: The first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1

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IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: a randomised, placebo-controlled, multiple ascending dose phase 1b study