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Depending on the route of administration (and the GLP-1R agonist used), peripherally administered GLP-1 analogs seem either to act directly in the hypothalamus and hindbrain, both areas with incomplete BBB, or else on vagal afferents to transmit the signal to the hindbrain which then projects to other key feeding areas in the brain

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81-LB: Novel microsphere technology reducing injection site reaction in the development of long-acting GLP-1 RA formulation