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Within this framework, absorption can be considered a metabolic control module: even when dietary composition appears adequate, altered gastrointestinal kinetics may reduce effective delivery of critical substrates, shifting metabolic constraint from nutrient intake to handling efficiency

Thirty-six per cent said they have decreased their alcohol consumption

In these patients, maintenance dosing is strongly preferred over complete discontinuation

Nausea, diarrhea, and vomiting most common

The dual composite endpoint of HbA1c below 7% plus 10% or more weight loss was achieved by 48% of mazdutide patients versus 21% on semaglutide

doi: 10.1177/0091270006289850