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MC4R agonists like setmelanotide are now approved for rare genetic obesity, cutting weight by ~710% and improving metabolism despite some skinpigment effects

Retatrutide NAFLD - Phase 2 Trial Results in Subset of Patients with Obesity and NAFLD

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Ribeiro A, Ferraz-de-Paula V, Pinheiro ML, Vitoretti LB, Mariano-Souza DP, Quinteiro-Filho WM, Akamine AT, Almeida VI, Quevedo J, Dal-Pizzol F, et al

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