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In conclusion, GLP-1RA is a promising candidate drug therapy for pediatric MASLD, and patients may benefit from metabolic improvement even if the liver disease ameliorating effects are not yet clear

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Lipotoxicity is the main feature of T2DM, but the protective effect of GLP-1 regulation of cholesterol efflux from pancreatic -cells against lipotoxicity has not been reported as of yet

Conversely, point estimates for tirzepatide showed a potential modest advantage for heart failure endpoints, with CIs compatible with no difference, consistent with recent data supporting protective effects of semaglutide and tirzepatide on heart failure outcomes and a potential incremental benefit with the latter 22

Physiology and clinical applications of GIP

No debe tomar Wegovy si a usted o a un miembro de su familia se le ha diagnosticado neoplasia endocrina mltiple tipo 2 o cncer medular de tiroides