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Conclusions In conclusion, the findings from this study underscore the potential of GE2 treatment as a promising therapeutic approach for reducing body weight, visceral fat, and inflammation in the dorsal and ventral hippocampus, as well as the amygdala, depending on sex and diet, while increasing neurogenesis and associative memory

392:427-437 [PubMed: 39555826] 401

This is consistent with previous studies providing evidence for hypothalamic control of sympathetic pre-autonomic neurons in the PVN 26 through the use of the same GABA A receptor antagonist 52

Apovian CM, Bergenstal RM, Cuddihy RM, Qu Y, Lenox S, Lewis MS, et al

Even small reductions in bioavailability due to degradation can meaningfully affect dose response, making it harder to distinguish true therapeutic response from reduced potency

Brain Circ